Humphreys E R, Isaacs K R, Raine T A, Saunders J, Stones V A, Wood D L
MRC Radiobiology Unit Chilton, Didcot, UK.
Int J Radiat Biol. 1993 Aug;64(2):231-5. doi: 10.1080/09553009314551341.
Four groups of 400 12-week-old CBA/H mice were injected i.p. with 69, 139, 280 and 550 Bqg-1 224Ra. A further group of 400 mice were injected i.p. with diluting solution only. The mice were then allowed unrestricted access to food and water until they died or were killed. 53 cases of myeloid leukaemia and 22 cases of osteosarcoma were confirmed in the 2000 mice injected, and for both tumour types direct relationships were shown to exist between the amount of 224Ra administered and the incidence of tumours. It is concluded that mouse is at a greater risk from myeloid leukaemia than from osteosarcoma in the region of administered 224Ra below that which causes a maximum yield of osteosarcoma. These results are discussed in the light of the present acceptance of osteosarcoma as the major risk to man from bone-seeking alpha-particle emitters.
将四组共400只12周龄的CBA/H小鼠腹腔注射69、139、280和550 Bqg-1的224Ra。另外一组400只小鼠仅腹腔注射稀释液。然后让小鼠自由获取食物和水，直至死亡或被处死。在注射的2000只小鼠中确诊了53例髓系白血病和22例骨肉瘤，对于这两种肿瘤类型，均显示所给予的224Ra量与肿瘤发生率之间存在直接关系。得出的结论是，在给予的224Ra量低于导致骨肉瘤最大产量的区域，小鼠患髓系白血病的风险高于骨肉瘤。根据目前认为骨肉瘤是亲骨性α粒子发射体对人类的主要风险这一观点，对这些结果进行了讨论。
