异丁司特对脑循环的药理作用：一项正电子发射断层扫描研究。
Pharmacological effects of ibudilast on cerebral circulation: a PET study.
作者信息
Fukuyama H, Kimura J, Yamaguchi S, Yamauchi H, Ogawa M, Doi T, Yonekura Y, Konishi J
机构信息
Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
出版信息
Neurol Res. 1993 Jun;15(3):169-73. doi: 10.1080/01616412.1993.11740130.
To evaluate the pharmacological effects of ibudilast on cerebral circulation, we examined 5 ischaemic stroke patients, using positron emission tomography, and we measured cerebral blood flow (CBF). Ibudilast loading per os led to a remarkable increase in CBF after 30 min. This CBF elevation was observed in the lesion side as well as in the nonlesion hemisphere. Therefore, we can confirm that ibudilast ameliorates the chronic low perfusion state of CBF in the ischaemic stroke patient.
为评估异丁司特对脑循环的药理作用，我们使用正电子发射断层扫描检查了5例缺血性中风患者，并测量了脑血流量（CBF）。口服异丁司特负荷剂量后30分钟，CBF显著增加。在病变侧以及非病变半球均观察到这种CBF升高。因此，我们可以证实异丁司特可改善缺血性中风患者CBF的慢性低灌注状态。
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