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Age-related proliferative activity in dermal melanocytic naevi detected by PCNA/cyclin expression.

作者信息

Tu P, Miyauchi S, Miki Y

机构信息

Department of Dermatology, University of Ehime School of Medicine, Japan.

出版信息

Br J Dermatol. 1993 Jul;129(1):65-8. doi: 10.1111/j.1365-2133.1993.tb03313.x.

DOI:10.1111/j.1365-2133.1993.tb03313.x
PMID:8103667
Abstract

A monoclonal antibody was used to demonstrate proliferating cell nuclear antigen in routine, formalin-fixed, paraffin-embedded tissue sections of dermal melanocytic naevi, including naevus naevocellularis partim lipomatodes, in different age-groups. The labelling indices of the melanocytic naevus cells were < 1% of those in the overlying epidermal basal cells, and showed a statistically significant decrease with ageing, and also in naevus naevocellularis partim lipomatodes, whereas the indices of the basal cells in the overlying interfollicular epidermis did not show any age-related changes.

摘要

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