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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Cubría C, Alvarez-Bujidos M, Negro A, Balaña-Fouce R, Ordóñez D

Departamento de Fisiología, Farmacología y Toxicología, Universidad de León, Spain.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Jun;105(2):251-4. doi: 10.1016/0742-8413(93)90203-w.

4',6-Diamidino-2-phenylindole is a powerful reversible inhibitor of porcine kidney diamine oxidase and partially purified rabbit liver S-adenosyl-L-methionine decarboxylase. 2. This diamidine has shown to be a competitive inhibitor of porcine kidney diamine oxidase with a Ki value of 13 microM. 3. A similar inhibitory pattern has been found on rat liver S-adenosyl-L-methionine decarboxylase with an estimated Ki of 21 microM.

4',6-二脒基-2-苯基吲哚是猪肾二胺氧化酶和部分纯化的兔肝S-腺苷-L-蛋氨酸脱羧酶的一种强效可逆抑制剂。2. 这种脒已被证明是猪肾二胺氧化酶的竞争性抑制剂，其Ki值为13微摩尔。3. 在大鼠肝S-腺苷-L-蛋氨酸脱羧酶上也发现了类似的抑制模式，估计Ki为21微摩尔。

Cubría C, Alvarez-Bujidos M, Negro A, Balaña-Fouce R, Ordóñez D

Departamento de Fisiología, Farmacología y Toxicología, Universidad de León, Spain.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Jun;105(2):251-4. doi: 10.1016/0742-8413(93)90203-w.

4',6-Diamidino-2-phenylindole is a powerful reversible inhibitor of porcine kidney diamine oxidase and partially purified rabbit liver S-adenosyl-L-methionine decarboxylase. 2. This diamidine has shown to be a competitive inhibitor of porcine kidney diamine oxidase with a Ki value of 13 microM. 3. A similar inhibitory pattern has been found on rat liver S-adenosyl-L-methionine decarboxylase with an estimated Ki of 21 microM.

4',6-二脒基-2-苯基吲哚是猪肾二胺氧化酶和部分纯化的兔肝S-腺苷-L-蛋氨酸脱羧酶的一种强效可逆抑制剂。2. 这种脒已被证明是猪肾二胺氧化酶的竞争性抑制剂，其Ki值为13微摩尔。3. 在大鼠肝S-腺苷-L-蛋氨酸脱羧酶上也发现了类似的抑制模式，估计Ki为21微摩尔。