Befani O, Shiozaki T S, Turini P, Gerosa P, Mondovi B
Department of Biochemical Sciences A. Rossi Fanelli, University of Rome La Sapienza, Italy.
Biochem Biophys Res Commun. 1995 Jul 17;212(2):589-94. doi: 10.1006/bbrc.1995.2010.
Metronidazole was found to be a non-competitive inhibitor of man, rabbit and rat intestinal diamine oxidases with an inhibition constant value of approximately 10(-4) M. The purified bovine serum amine oxidase was not inhibited, whereas the purified swine kidney enzyme gave similar results. These findings suggest that metronidazole and similar compounds, used as antibacterial and antiprotozoal drugs, should be given under careful control, especially when administered for long times, because a decrease of intestinal diamine oxidase activity was proven to be a risk factor for several pathologies of this organ.
已发现甲硝唑是人和兔、大鼠肠道二胺氧化酶的非竞争性抑制剂，抑制常数约为10⁻⁴ M。纯化的牛血清胺氧化酶未受抑制，而纯化的猪肾酶得到了类似结果。这些发现表明，作为抗菌和抗原虫药物使用的甲硝唑及类似化合物应在严格控制下给药，尤其是长期给药时，因为肠道二胺氧化酶活性降低已被证明是该器官多种病变的一个风险因素。
