Ikeda A, Sugano M
Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture, Fukuoka, Japan.
Ann Nutr Metab. 1993;37(3):101-9. doi: 10.1159/000177757.
The effect of dietary protein, either casein (CAS) or soybean protein (SOY), on the polyunsaturated fatty acid (PUFA) composition of liver microsomal phospholipids and eicosanoid production was compared in normal and streptozotocin-induced diabetic rats fed diets containing perilla oil rich in alpha-linolenic acid. In normal rats the linoleic acid desaturation index in liver microsomal phospholipids was significantly higher in the CAS group than in the SOY group, whereas it was reversed in diabetic rats. The proportion of eicosapentaenoic acid (EPA) decreased in diabetic rats, in particular those fed SOY, whereas it was vice versa for arachidonic acid (AA). The ratio of aortic prostacyclin production to platelet thromboxane A2 production decreased only in diabetic rats fed SOY reflecting a reduction of the EPA/AA ratio. Thus, dietary protein differently modified the PUFA composition and eicosanoid balance even in the diabetic rat. In this respect, alpha-linolenic acid seemed to be less influential than linoleic acid.
在喂食富含α-亚麻酸的紫苏油日粮的正常大鼠和链脲佐菌素诱导的糖尿病大鼠中，比较了酪蛋白（CAS）或大豆蛋白（SOY）这两种膳食蛋白对肝脏微粒体磷脂多不饱和脂肪酸（PUFA）组成和类二十烷酸生成的影响。在正常大鼠中，肝脏微粒体磷脂中的亚油酸去饱和指数在CAS组显著高于SOY组，而在糖尿病大鼠中则相反。糖尿病大鼠中二十碳五烯酸（EPA）的比例降低，尤其是喂食SOY的大鼠，而花生四烯酸（AA）则相反。仅在喂食SOY的糖尿病大鼠中，主动脉前列环素生成与血小板血栓素A2生成的比率降低，这反映了EPA/AA比率的降低。因此，即使在糖尿病大鼠中，膳食蛋白对PUFA组成和类二十烷酸平衡的影响也不同。在这方面，α-亚麻酸似乎比亚油酸的影响小。
