口服昂丹司琼对健康男性在CCK-4惊恐激发试验后血浆总胆囊收缩素水平的影响。
Effect of oral ondansetron on total cholecystokinin plasma levels following CCK-4 panic challenge procedure in healthy men.
作者信息
Dépôt M, Merani S, Bradwejn J, Mukherjee J, Caillé J, Gutkowska J, Caillé G
机构信息
Université de Montréal, Faculty of Medicine, Department of Pharmacology, Que.
出版信息
J Psychiatry Neurosci. 1998 Nov;23(5):298-304.
OBJECTIVE
To gain insight into whether ondansetron treatment induces changes in total cholecystokinin (CCKT) plasma levels before and after administration of the cholecystokinin tetrapeptide (CCK-4) panic challenge procedure in healthy men.
METHODS
Thirty-eight volunteers received a 50-microgram bolus of CCK-4 60 minutes after a single oral dose (acute treatment) and multiple oral doses (chronic treatment) of ondansetron or placebo.
RESULTS
Results showed no difference in CCKT plasma levels of CCKT elimination rate constant between the ondansetron and the placebo groups after either acute or chronic treatment.
CONCLUSION
Results from this study suggest that total CCK plasma levels are not influenced by either acute or chronic treatment with ondansetron. However, the effect of ondansetron on the different CCK component fractions still needs exploration.
目的
了解在健康男性中，昂丹司琼治疗是否会在给予胆囊收缩素四肽（CCK-4）惊恐激发程序前后引起血浆总胆囊收缩素（CCKT）水平的变化。
方法
38名志愿者在单次口服剂量（急性治疗）和多次口服剂量（慢性治疗）的昂丹司琼或安慰剂后60分钟接受50微克CCK-4推注。
结果
结果显示，无论是急性治疗还是慢性治疗后，昂丹司琼组和安慰剂组的CCKT血浆水平及CCKT消除速率常数均无差异。
结论
本研究结果表明，急性或慢性昂丹司琼治疗均不会影响血浆总CCK水平。然而，昂丹司琼对不同CCK组分的影响仍有待探索。
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