胃肠道类癌的免疫组织化学分析
Immunohistochemical analysis of gastrointestinal carcinoids.
作者信息
Hayashi H, Nakagawa M, Kitagawa S, Yamada T, Ishida K, Kurumaya H
机构信息
Department of Surgery, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.
出版信息
Gastroenterol Jpn. 1993 Aug;28(4):483-90. doi: 10.1007/BF02776945.
Clinicopathological and immunohistochemical analyses were performed on ten samples of gastrointestinal carcinoids resected in Ishikawa Prefectural Central Hospital. All samples showed positive reaction to chromogranin A. Serotonin was detected in 8 samples, somatostatin in 4 samples, gastrin in 2 samples. Glucagon/Glicentin in 1 sample, and PYY production in 2 samples. CEA production was detected in 8 samples, and microvascular invasion was observed in 6 of these 8 patients. The PCNA/cyclin labeling index (L.I.) of the cases with metastases was significantly higher than those without metastases. In conclusion, the expression of CEA and the PCNA/cyclin L.I. may be useful markers of the malignant potential of carcinoid tumors.
对在石川县立中央医院切除的10例胃肠道类癌样本进行了临床病理和免疫组化分析。所有样本对嗜铬粒蛋白A均呈阳性反应。在8个样本中检测到5-羟色胺，4个样本中检测到生长抑素，2个样本中检测到胃泌素。1个样本中检测到胰高血糖素/胰高血糖素样肽，2个样本中检测到PYY分泌。在8个样本中检测到癌胚抗原（CEA）分泌，在这8例患者中的6例观察到微血管侵犯。有转移病例的增殖细胞核抗原/细胞周期蛋白标记指数（L.I.）显著高于无转移病例。总之，CEA的表达和PCNA/细胞周期蛋白L.I.可能是类癌肿瘤恶性潜能的有用标志物。
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