Sanyal D, Williams A J, Johnson A P, George R C
Public Health Laboratory, Northern General Hospital, Sheffield.
J Hosp Infect. 1993 Jul;24(3):167-73. doi: 10.1016/0195-6701(93)90046-3.
Intraperitoneal vancomycin is used in the treatment of peritonitis in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). We describe the emergence of low-level glycopeptide-resistance in five Gram-positive species over a one-year period. Isolation of these organisms was associated with vancomycin treatment failure in four patients who had had numerous episodes of peritonitis. Clinicians and microbiologists should be aware that repeated administration of glycopeptides to such patients might lead to the emergence of organisms resistant to these antibiotics.
腹腔内注射万古霉素用于治疗持续非卧床腹膜透析（CAPD）患者的腹膜炎。我们描述了在一年时间里五种革兰氏阳性菌中出现低水平糖肽耐药性的情况。这些微生物的分离与四名有多次腹膜炎发作史的患者的万古霉素治疗失败有关。临床医生和微生物学家应意识到，对此类患者反复使用糖肽类药物可能会导致对这些抗生素产生耐药性的微生物出现。
