人类配对结构域基因PAX7（Hup1）定位于1号染色体的1p35 - 1p36.2区域。
The human paired domain gene PAX7 (Hup1) maps to chromosome 1p35-1p36.2.
作者信息
Schäfer B W, Mattei M G
机构信息
University of Zurich, Department of Pediatrics, Switzerland.
出版信息
Genomics. 1993 Jul;17(1):249-51. doi: 10.1006/geno.1993.1315.
The human PAX7 gene encodes a protein containing a domain homologous to the Drosophila paired box first described in three segmentation genes. In addition to the paired box, the gene contains the conserved octapeptide and a paired-type homeobox. Two of the five known human PAX genes have been implicated in human disorders so far. Here we have used a somatic cell hybrid panel to localize PAX7 to human chromosome 1. In situ hybridization shows that PAX7 is confined to the short arm of chromosome 1 at 1p35-1p36.2.
人类PAX7基因编码一种蛋白质，该蛋白质含有一个与果蝇配对盒同源的结构域，此配对盒最早在三个体节基因中被描述。除了配对盒外，该基因还包含保守的八肽和一个配对型同源异型框。到目前为止，五个已知的人类PAX基因中有两个与人类疾病有关。在这里，我们使用体细胞杂交板将PAX7定位到人类1号染色体上。原位杂交显示，PAX7定位于1号染色体短臂的1p35-1p36.2区域。
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