Li R, Nortamo P, Kantor C, Kovanen P, Timonen T, Gahmberg C G
Department of Biochemistry, University of Helsinki, Finland.
J Biol Chem. 1993 Oct 15;268(29):21474-7.
Adhesion is of pivotal importance for a number of leukocyte functions. Little is known about the binding between leukocyte integrins and the intercellular adhesion molecules (ICAMs). Normally integrins are nonadhesive, and require a stimulus to become active. We have now identified a peptide from ICAM-2, which binds to leukocyte integrins and activates adhesion. Furthermore, the peptide strongly increased the binding and cytotoxicity of natural killer cells. These findings show that adhesion-dependent leukocyte functions can be activated by ligand-derived peptides, and therefore provide evidence that the avidity of leukocyte integrins is up-regulated by integrin-ligand interactions.
黏附对于多种白细胞功能至关重要。关于白细胞整合素与细胞间黏附分子（ICAMs）之间的结合，我们所知甚少。正常情况下，整合素不具有黏附性，需要刺激才能激活。我们现已从ICAM - 2中鉴定出一种肽，它能与白细胞整合素结合并激活黏附。此外，该肽显著增强了自然杀伤细胞的结合能力和细胞毒性。这些发现表明，依赖黏附的白细胞功能可被配体衍生肽激活，因此提供了证据，证明白细胞整合素的亲和力通过整合素 - 配体相互作用而上调。
