2-羟丙基-β-环糊精对胸腺五肽的稳定作用及其药理性质的保留
Stabilization of thymopentin and preservation of its pharmacological properties by 2-hydroxypropyl-beta-cyclodextrin.
作者信息
Brown N D, Butler D L, Chiang P K
机构信息
Department of Applied Biochemistry, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
出版信息
J Pharm Pharmacol. 1993 Jul;45(7):666-7. doi: 10.1111/j.2042-7158.1993.tb05675.x.
Thymopentin prepared in 5, 15, and 20% 2-hydroxypropyl-beta-cyclodextrin (HPCD) was able to inhibit guinea-pig ileum contraction stimulated by anatoxin-a (3 x 10(-6) M) after fourteen months of storage at room temperature. Thus, in contrast to the instability of thymopentin prepared without HPCD, the pharmacological activity was retained and could be stored in a ready-to-use solution for extended periods without refrigeration.
用5%、15%和20%的2-羟丙基-β-环糊精（HPCD）制备的胸腺五肽，在室温下储存14个月后，能够抑制由anatoxin-a（3×10⁻⁶ M）刺激引起的豚鼠回肠收缩。因此，与未添加HPCD制备的胸腺五肽的不稳定性相反，其药理活性得以保留，并且可以在无需冷藏的即用型溶液中长期储存。
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