人类和黑猩猩的主要组织相容性复合体II类多态性

Major histocompatibility complex class II polymorphisms in humans and chimpanzees.

作者信息

Bontrop R E, Kenter M, Otting N, Jonker M

机构信息

Department of Chronic and Infectious Diseases, ITRI-TNO, Rijswijk, The Netherlands.

出版信息

J Med Primatol. 1993 Jan;22(1):50-6.

PMID:8105089

Abstract

Allelic variation at the MhcPatr-DR and -DQ loci was studied by molecular biological techniques and compared to available HLA data. With regard to the number of allelic lineages, the chimpanzee shows a condensation of its major histocompatibility complex (MHC) class II repertoire as compared to humans. This does not have an impact on the overall degree of MHC class II polymorphism in the chimpanzee since a few lineages that are oligomorphic in humans display an extensive degree of polymorphism in the chimpanzee.

摘要

通过分子生物学技术研究了黑猩猩MhcPatr - DR和 - DQ基因座的等位基因变异，并与现有的人类白细胞抗原（HLA）数据进行了比较。就等位基因谱系的数量而言，与人类相比，黑猩猩的主要组织相容性复合体（MHC）II类基因库出现了浓缩。但这对黑猩猩MHC II类多态性的总体程度没有影响，因为在人类中呈寡态的少数谱系在黑猩猩中表现出广泛的多态性。