McAdam S N, Boyson J E, Liu X, Garber T L, Hughes A L, Bontrop R E, Watkins D I
Wisconsin Regional Primate Research Center, Madison, USA.
J Immunol. 1995 Jun 15;154(12):6421-9.
There are nearly 50 alleles at the highly polymorphic HLA-A class I locus that fall into six distinct families. To determine the allelic repertoire and the mechanism of generation of diversity of the A locus in primates we have analyzed A locus alleles from 28 apparently unrelated chimpanzees (Pan troglodytes) and bonobos (Pan paniscus). We have, therefore, compared the sequences of 19 HLA-A homologues from chimpanzees and bonobos to 42 HLA-A sequences. HLA-A homologues were well preserved in chimpanzees and bonobos with very few new substitutions present in the A locus alleles of both species of chimpanzee. Surprisingly, all chimpanzees and bonobos expressed A locus alleles related to only one of the six families of human HLA-A alleles. This suggests that the common ancestor of these two species either passed through a genetic bottleneck or that selection has favored the maintenance of the HLA-A1, -A3, -A11 family in chimpanzees.
在高度多态的HLA - A I类基因座上有近50个等位基因，它们分属于六个不同的家族。为了确定灵长类动物中A基因座的等位基因库以及多样性产生的机制，我们分析了28只明显无亲缘关系的黑猩猩（Pan troglodytes）和倭黑猩猩（Pan paniscus）的A基因座等位基因。因此，我们将来自黑猩猩和倭黑猩猩的19个HLA - A同源序列与42个HLA - A序列进行了比较。HLA - A同源序列在黑猩猩和倭黑猩猩中保存良好，这两个黑猩猩物种的A基因座等位基因中几乎没有新的替换。令人惊讶的是，所有黑猩猩和倭黑猩猩表达的A基因座等位基因仅与人类HLA - A等位基因六个家族中的一个相关。这表明这两个物种的共同祖先要么经历了遗传瓶颈，要么是选择有利于在黑猩猩中维持HLA - A1、-A3、-A11家族。
