Yasuda M, Minamitani N, Maeda K
Department of Psychiatry and Neurology, Kobe University School of Medicine, Japan.
Jpn J Psychiatry Neurol. 1993 Mar;47(1):85-90. doi: 10.1111/j.1440-1819.1993.tb02034.x.
Immunoreactivities (IRs) of peptide histidine methionine (PHM) as well as somatostatin and vasoactive intestinal peptide (VIP) in the cerebrospinal fluid (CSF) were measured in patients with senile dementia of the Alzheimer type (SDAT) and age-matched control subjects. We found statistically significant reductions in the PHM-IR and somatostatin-IR levels in the CSF from patients with SDAT, as compared with those of the controls. However, the VIP-IR level in the CSF from SDAT was not different from that of the controls. These results suggest that selective degeneration of neurons containing somatostatin and PHM or the alteration in metabolism of PHM in the CSF might occur in SDAT.
在阿尔茨海默型老年痴呆症（SDAT）患者及年龄匹配的对照受试者中，测量了脑脊液（CSF）中肽组氨酸甲硫氨酸（PHM）以及生长抑素和血管活性肠肽（VIP）的免疫反应性（IRs）。我们发现，与对照组相比，SDAT患者脑脊液中PHM-IR和生长抑素-IR水平在统计学上有显著降低。然而，SDAT患者脑脊液中的VIP-IR水平与对照组并无差异。这些结果表明，SDAT可能发生含生长抑素和PHM的神经元选择性变性或脑脊液中PHM代谢改变。
