阿尔茨海默型老年痴呆症患者脑脊液中β-内啡肽样免疫反应性水平降低。

Decreased level of beta-endorphin-like immunoreactivity in cerebrospinal fluid of patients with senile dementia of Alzheimer type.

作者信息

Kaiya H, Tanaka T, Takeuchi K, Morita K, Adachi S, Shirakawa H, Ueki H, Namba M

出版信息

Life Sci. 1983 Sep 12;33(11):1039-43. doi: 10.1016/0024-3205(83)90658-6.

Abstract

beta-Endorphin-like immunoreactivity in cerebrospinal fluid(CSF) was observed to decrease in patients with Huntington's disease and dementia due to brain vascular disease. The greatest decrease was seen in patients with presenile and senile dementia of Alzheimer type(SDAT). The immunoreactivity significantly correlated with psychological functions when examined using a dementia rating scale (r=0.51, p less than 0.01, for all dementia, r=0.65, p less than 0.02, for only SDAT). These results suggest that a B-endorphin-like substance may be related in the pathophysiology of dementia.

摘要

在患有亨廷顿舞蹈症和脑血管疾病所致痴呆症的患者中，观察到脑脊液（CSF）中的β - 内啡肽样免疫反应性降低。在早老性和老年性阿尔茨海默型痴呆（SDAT）患者中下降最为明显。当使用痴呆评定量表进行检查时，免疫反应性与心理功能显著相关（对于所有痴呆患者，r = 0.51，p < 0.01；仅对于SDAT患者，r = 0.65，p < 0.02）。这些结果表明，一种β - 内啡肽样物质可能与痴呆症的病理生理学有关。