Levy H B, Baer G, Baron S, Buckler C E, Gibbs C J, Iadarola M J, London W T, Rice J
J Infect Dis. 1975 Oct;132(4):434-9. doi: 10.1093/infdis/132.4.434.
A comlex of polyriboinosinic-polyribocytidylic acid (poly I-poly C) with poly-L-lysine and carboxymethylcellulose has been prepared. This complex is five to 10 times as resistant to hydrolysis by primate serum as the parent poly I-poly C. It has a thermal denaturation temperature about 40 C higher than that of poly I-poly C. The complex induces significant levels of serum interferon in monkeys and chimpanzees under conditions in which poly I-poly C itself induces no interferon.
已制备出聚肌苷酸-聚胞苷酸（聚I-聚C）与聚-L-赖氨酸和羧甲基纤维素的复合物。该复合物对灵长类动物血清水解的抗性是母体聚I-聚C的5至10倍。其热变性温度比聚I-聚C高约40℃。在聚I-聚C本身不诱导干扰素的条件下，该复合物能在猴子和黑猩猩中诱导出显著水平的血清干扰素。
