Whartenby K A, Insel R A, Freeman S M, Keng P, Abraham G N
Department of Microbiology and Immunology, University of Rochester Medical Center, NY 14642.
Acta Virol. 1993 Apr-Jun;37(2-3):113-22.
The human genome contains a large number of endogenous retroviral-related sequences. While the function of these sequences is unknown, they may contribute to disease processes through their regions of homology with infectious retroviruses. We have been further characterizing a recently reported HTLV-1 related endogenous retroviral sequence cloned from T lymphocytes isolated from a patient with essential cryoglobulinemia. We here report further detailed transcriptional analysis of the sequence for tissue and cell-cycle specificity and a novel finding of an association between the endogenous retrovirus and a ras-related gene.
人类基因组包含大量与内源性逆转录病毒相关的序列。虽然这些序列的功能尚不清楚，但它们可能通过与感染性逆转录病毒的同源区域对疾病进程产生影响。我们一直在进一步研究最近报道的从一名患有原发性冷球蛋白血症患者分离的T淋巴细胞中克隆出的与HTLV-1相关的内源性逆转录病毒序列。我们在此报告该序列在组织和细胞周期特异性方面更详细的转录分析，以及内源性逆转录病毒与一个ras相关基因之间关联的新发现。
