Shimomura A, Tahara D, Azekura H
Division of Nephrology, Hamamatsu Medical Center, Japan.
Adv Perit Dial. 1993;9:80-6.
One of the key factors in improving the survival and dropout rate in continuous ambulatory peritoneal dialysis (CAPD) patients is to improve their nutritional status. In this study 18 CAPD patients were encouraged to add 0.1-0.3 g of protein/kilogram/day of high biological value nutrients for more than 6 months in the form of a dessert. Several nutritional parameters, such as serum total protein, albumin, prealbumin, transferrin, plasma total amino acids, the ratio of essential amino acids (EAA) to nonessential amino acids (NEAA), and serum C3, C4, increased significantly. The values of (KT/V) urea increased simultaneously with increases in the protein catabolic rate (PCR) after the administration of nutrients. There was also a significant correlation between the (KT/V) urea and PCR in each patient. These results suggest that supplementary protein nutrients can improve the biochemical and physical nutritional parameters that are related to nutritional status and peritoneal functions.
改善持续性非卧床腹膜透析（CAPD）患者生存率和降低退出率的关键因素之一是改善其营养状况。在本研究中，18名CAPD患者被鼓励以甜点的形式，每天额外补充0.1 - 0.3克/千克具有高生物价值的营养素，持续6个月以上。几个营养参数，如血清总蛋白、白蛋白、前白蛋白、转铁蛋白、血浆总氨基酸、必需氨基酸（EAA）与非必需氨基酸（NEAA）的比例以及血清C3、C4，均显著增加。给予营养物质后，尿素清除率（KT/V）值随蛋白质分解代谢率（PCR）的增加而同时升高。每位患者的尿素清除率（KT/V）与PCR之间也存在显著相关性。这些结果表明，补充蛋白质营养素可改善与营养状况和腹膜功能相关的生化和身体营养参数。
