Tsai Y L, Wu S J, Chen Y M, Hsieh B S
Department of Obstetrics and Gynecology, Provincial Tao-Yuan Hospital, Taiwan, R.O.C.
J Formos Med Assoc. 1993 Jun;92(6):514-8.
In order to observe the sequential changes in the renin-angiotensin-aldosterone system (RAAS) in hypertensive pregnancies, blood and urine samples of pregnant women were collected every four weeks from the 20th week of gestation to the fourth week after delivery in a consecutive and prospective study. Nine subjects developed pregnancy-induced hypertension in later gestation, and six of them with proteinuria were classified as having preeclampsia. The gestational ages at the onset of hypertension were the 28th week for one patient, the 32nd week for three patients and the 36th week for five patients. Plasma renin activity in most of the cases decreased to non-pregnant levels after hypertension was established, while the plasma aldosterone level did not. Marked variations in daily sodium and potassium excretion were observed at the various gestational weeks, while serum concentrations of these electrolytes changed only within a narrow range. No correlation between the changes in RAAS and electrolytes were shown in our cases.
为了观察妊娠期高血压患者肾素 - 血管紧张素 - 醛固酮系统（RAAS）的序贯变化，在一项连续的前瞻性研究中，从妊娠第20周开始至产后第4周，每四周采集孕妇的血液和尿液样本。9名受试者在妊娠后期发生了妊娠期高血压，其中6名伴有蛋白尿的患者被归类为子痫前期。高血压发病时的孕周，1例患者为第28周，3例患者为第32周，5例患者为第36周。在大多数病例中，高血压确立后血浆肾素活性降至非妊娠水平，而血浆醛固酮水平则未下降。在不同孕周观察到每日钠和钾排泄量有明显变化，而这些电解质的血清浓度仅在狭窄范围内变化。在我们的病例中，未显示RAAS变化与电解质之间存在相关性。
