Voronina T A, Molodavkin G M, Ramkhin E Ia
Eksp Klin Farmakol. 1993 May-Jun;56(3):3-5.
Behavioral methods were used to examine the features of effects of fenazepam. gidazepam, and medazepam in young and mature non-inbred albino male rats. There were age- [correction of sex-]specific differences in responses to a drug. The higher effects the drug possesses, the greater differences there are in its effects on animals of different ages. It is suggested that different maturities of benzodiazepine receptors can affect the behavior of rats of different ages in the proposed tests.
采用行为学方法研究了氟硝西泮、吉地西泮和美达西泮对未近交的年轻和成年白化雄性大鼠的作用特点。药物反应存在年龄特异性差异。药物的作用越强,其对不同年龄动物的作用差异就越大。研究表明,苯二氮䓬受体的不同成熟度可能会影响所提议试验中不同年龄大鼠的行为。