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[氟硝西泮和苯巴比妥对大鼠孕期进程及其子代早期产后发育的影响]

[The effect of fenazepam and phenobarbital on the course of pregnancy in rats and on the early postnatal development of their progeny].

作者信息

Chobanov N G, Voronina T A, Liubimov B I, Smol'nikova N M, Nemova E P

出版信息

Eksp Klin Farmakol. 1993 Jul-Aug;56(4):36-7.

PMID:8106058
Abstract

Examining the effects of phenazepam and phenobarbital on the course of pregnancy and the development of offsprings has revealed that phenobarbital that has an embryotoxic effect reduced the number of rat offsprings and diminished their weight, but failed to affect the behavioral responses of newborn rats. On the contrary, phenazepam had no embryotoxic effect, but on entering the newborn rats' organism with milk it inhibited some behavioral reactions in the early postnatal period.

摘要

研究非那西泮和苯巴比妥对妊娠过程及后代发育的影响后发现,具有胚胎毒性作用的苯巴比妥减少了大鼠后代数量并降低了其体重,但未影响新生大鼠的行为反应。相反,非那西泮没有胚胎毒性作用,但通过乳汁进入新生大鼠体内后,它在出生后早期抑制了一些行为反应。

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