Kehrl J H, Deguchi Y
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Leuk Lymphoma. 1993 Jun;10(3):173-6. doi: 10.3109/10428199309145879.
Two human homeobox genes, HB9 and HLX, are expressed in hematopoietic progenitors and activated lymphocytes. They are implicated in the proliferation of hematopoietic progenitors in response to growth factors and the differentiation of hematopoietic progenitors to mature cell lineages. RNAs from bone marrow cells of patients with acute myeloid or lymphocytic leukemia have high levels of these two genes while similar RNAs from patients with chronic lymphocytic or myeloid leukemias have nearly normal levels. While the significance of these two genes in leukemogenesis is unknown, they are likely to regulate gene transcription during hematopoiesis and their dysregulation may have dire consequences for hematopoietic cells.
两个人类同源盒基因HB9和HLX在造血祖细胞和活化淋巴细胞中表达。它们与造血祖细胞对生长因子的增殖反应以及造血祖细胞向成熟细胞谱系的分化有关。急性髓性或淋巴细胞白血病患者骨髓细胞的RNA中这两个基因水平较高，而慢性淋巴细胞或髓性白血病患者的类似RNA水平接近正常。虽然这两个基因在白血病发生中的意义尚不清楚，但它们可能在造血过程中调节基因转录，其失调可能对造血细胞产生严重后果。
