Meyer C G, Schnittger L
Department of Molecular Biology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Hum Immunol. 1993 Oct;38(2):123-6. doi: 10.1016/0198-8859(93)90528-9.
A novel HLA-DPB1 allele (DPB1*/A6) has been identified in West Africa, and the occurrence of the recently reported allele DPB14001 (DPB1BRI-5) in Negroid populations has been confirmed DPB1WA6 differs from DPB10101 by a silent nucleotide exchange at codon position 43 only. It constitutes, thereby, a link to DPB11101, 1501, and 2601 and suggests and evolutionary relationship with these alleles. Carrying the same silent mutation, DPB11101, 1501, and 2601 may, by recombinations, have evolved from DPB1WA6. An apparently older evolutionary branch arose directly from DPB10101 and comprises the closely related alleles DPB12701 and DPB14001 reported only from individuals of African descent.
在西非发现了一种新的HLA - DPB1等位基因（DPB1*/A6），并且已证实最近报道的等位基因DPB14001（DPB1BRI - 5）在黑人种群中的出现。DPB1WA6与DPB10101仅在密码子位置43处有一个沉默核苷酸交换的差异。因此，它构成了与DPB11101、1501和2601的联系，并表明与这些等位基因存在进化关系。携带相同沉默突变的DPB11101、1501和2601可能通过重组从DPB1WA6进化而来。一个明显更古老的进化分支直接从DPB10101产生，包括仅在非洲裔个体中报道的密切相关的等位基因DPB12701和DPB14001。
