在撒哈拉以南非洲地区发现了三个新的DP等位基因：DPB17401、DPA102013和DPA1*0302。

Three new DP alleles identified in sub-Saharan Africa: DPB17401, DPA102013, and DPA1*0302.

作者信息

Steiner L L, Cavalli A, Zimmerman P A, Boatin B A, Titanji V P, Bradley J E, Lucius R, Nutman T B, Begovich A B

机构信息

Department of Human Genetics, Roche Molecular Systems, Alameda, CA 94501, USA.

出版信息

Tissue Antigens. 1998 Jun;51(6):653-7. doi: 10.1111/j.1399-0039.1998.tb03009.x.

DOI:10.1111/j.1399-0039.1998.tb03009.x

PMID:9694359

Abstract

HLA-DP genotyping of over 400 individuals from sub-Saharan Africa identified three new DP alleles: DPB17401, DPA102013, and DPA10302. DNA sequencing confirmed that DPB17401, found in one individual, is a novel combination of previously described sequence motifs in the six variable regions of DPB1. DPA102013, found in one individual, is identical to DPA102012 except for two silent substitutions, a T to C transition in codon 37, and an A to G transition in codon 38. DPA10302, identified in seven individuals, is identical to DPA10301 except for a C to T transition at the second position of codon 66. The identification of these novel alleles brings the total number of reported DPB1 alleles to 77 and DPA1 alleles to 11.

摘要

对来自撒哈拉以南非洲地区的400多名个体进行的HLA-DP基因分型，鉴定出三个新的DP等位基因：DPB17401、DPA102013和DPA10302。DNA测序证实，在一名个体中发现的DPB17401是DPB1六个可变区中先前描述的序列基序的新组合。在一名个体中发现的DPA102013与DPA102012相同，只是有两个沉默替换，密码子37处的T到C转换以及密码子38处的A到G转换。在七名个体中鉴定出的DPA10302与DPA10301相同，只是密码子66第二位的C到T转换。这些新等位基因的鉴定使已报道的DPB1等位基因总数达到77个，DPA1等位基因总数达到11个。