Greenman Y, Melmed S
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048-1865.
J Clin Endocrinol Metab. 1994 Feb;78(2):398-403. doi: 10.1210/jcem.78.2.8106629.
The expression of two somatostatin receptor subtypes, SSTR1 and SSTR2, was studied in 27 pituitary tumors and 1 chronic lymphocytic leukemia pituitary infiltrate. Solution hybridization techniques were used for RNA analysis. SSTR1 and SSTR2 were, respectively, expressed in 3 of 7 and 9 of 10 GH-secreting tumors, 1 of 9 and 5 of 9 nonfunctioning tumors, 4 of 5 and 0 of 5 of prolactinomas, and 1 of 3 and 0 of 3 ACTH-secreting tumors. The chronic lymphocytic leukemia infiltrate expressed the SSTR2 subtype. No correlation was detected among tumor size, level of hormonal hypersecretion, and somatostatin receptor expression status. Two acromegalic patients who responded to octreotide therapy exclusively expressed the SSTR2 subtype in their tumors. The results indicate that two SSTR subtypes are heterogeneously expressed in different pituitary adenoma cell types.
在27例垂体瘤和1例慢性淋巴细胞白血病垂体浸润病例中研究了两种生长抑素受体亚型SSTR1和SSTR2的表达。采用溶液杂交技术进行RNA分析。SSTR1和SSTR2分别在7例生长激素分泌性肿瘤中的3例、10例中的9例，9例无功能肿瘤中的1例、9例中的5例，5例催乳素瘤中的4例、5例中的0例，以及3例促肾上腺皮质激素分泌性肿瘤中的1例、3例中的0例中表达。慢性淋巴细胞白血病浸润表达SSTR2亚型。未检测到肿瘤大小、激素分泌过多水平和生长抑素受体表达状态之间的相关性。两名对奥曲肽治疗有反应的肢端肥大症患者，其肿瘤中仅表达SSTR2亚型。结果表明，两种SSTR亚型在不同垂体腺瘤细胞类型中呈异质性表达。
