Preac-Mursic V, Pfister H W, Spiegel H, Burk R, Wilske B, Reinhardt S, Böhmer R
Max v. Pettenkofer Institut für Hygiene u. Medizinische Mikrobiologie, LM-Universität München, Germany.
J Clin Neuroophthalmol. 1993 Sep;13(3):155-61; discussion 162.
The persistence of Borrelia burgdorferi in six patients is described. Borrelia burgdorferi has been cultivated from iris biopsy, skin biopsy, and cerebrospinal fluid also after antibiotic therapy for Lyme borreliosis. Lyme Serology: IgG antibodies to B. burgdorferi were positive, IgM negative in four patients; in two patients both IgM and IgG were negative. Antibiotic therapy may abrogate the antibody response to the infection as shown by our results. Patients may have subclinical or clinical disease without diagnostic antibody titers. Persistence of B. burgdorferi cannot be excluded when the serum is negative for antibodies against it.
本文描述了6例伯氏疏螺旋体持续感染的患者。在莱姆病螺旋体病患者接受抗生素治疗后，仍可从虹膜活检、皮肤活检以及脑脊液中培养出伯氏疏螺旋体。莱姆病血清学检查：4例患者抗伯氏疏螺旋体IgG抗体呈阳性，IgM抗体呈阴性；2例患者IgM和IgG抗体均呈阴性。我们的研究结果表明，抗生素治疗可能会消除机体对感染的抗体反应。患者可能患有亚临床或临床疾病，但抗体滴度却未达到诊断标准。当血清中抗伯氏疏螺旋体抗体呈阴性时，不能排除伯氏疏螺旋体持续感染的可能性。
