van der Giessen W J, Slager C J, Gussenhoven E J, van Beusekom H M, Huijts R A, Schuurbiers J C, Wilson R A, Serruys P W, Verdouw P D
Department of Cardiology, Thoraxcentre, Erasmus University Rotterdam, The Netherlands.
Int J Card Imaging. 1993 Sep;9(3):219-26. doi: 10.1007/BF01145324.
A polyethylene-terephthalate (PETP, polyester), self-expanding, braided mesh stent has been developed for percutaneous (coronary) arterial implantation. In vitro measurements showed that the radial pressure delivered by this device was similar to a self-expanding, stainless steel stent. Due to hysteresis-like behaviour, it proved necessary to mount the polymer stent on the delivery system immediately before the placement procedure, and to select a diameter in the unconstrained condition, which was 60% larger than the diameter of the target vessel. Eight polyester stents were implanted in peripheral arteries of four pigs. Except for heparin during the implantation procedure, antithrombotic or antiplatelet drugs were not administered. After four weeks repeat angiography revealed that one of the stents was subtotally occluded. At autopsy, two other stents proved to be located in the aortic bifurcation, probably due to failure of the delivery system. Quantitative angiographic assessment showed that the mean luminal diameters at the site of stent placement were 3.3 +/- 0.2 mm before, 3.2 +/- 0.2 mm immediately after, and 2.7 +/- 0.5 mm at four weeks after implantation. Intravascular ultrasound (IVUS) examination after 4 weeks could identify the individual struts of the stents, as well as their length. In addition, a description of the extent of neointimal hyperplasia was feasible. The IVUS assessment was validated by histological examination. In conclusion, polyester stents can be constructed with mechanical properties similar to stainless steel stents. After implantation in porcine peripheral arteries, five of six correctly placed stents were patent at four weeks. Imaging of stents by angiography and IVUS provided complementary information.
一种聚对苯二甲酸乙二酯（PETP，聚酯）自膨胀编织网状支架已被研发用于经皮（冠状动脉）动脉植入。体外测量表明，该装置产生的径向压力与自膨胀不锈钢支架相似。由于类似滞后的行为，事实证明有必要在放置手术前立即将聚合物支架安装在输送系统上，并在无约束状态下选择一个直径，该直径比目标血管直径大60%。八个聚酯支架被植入四只猪的外周动脉。除了在植入过程中使用肝素外，未给予抗血栓或抗血小板药物。四周后重复血管造影显示，其中一个支架几乎完全闭塞。尸检时，另外两个支架被证明位于主动脉分叉处，可能是由于输送系统故障。定量血管造影评估显示，支架植入部位的平均管腔直径在植入前为3.3±0.2毫米，植入后立即为3.2±0.2毫米，植入四周后为2.7±0.5毫米。四周后的血管内超声（IVUS）检查可以识别支架的各个支柱及其长度。此外，对新生内膜增生程度的描述是可行的。IVUS评估通过组织学检查得到验证。总之，聚酯支架可以构建成具有与不锈钢支架相似的机械性能。在猪外周动脉植入后，六个正确放置的支架中有五个在四周时仍保持通畅。血管造影和IVUS对支架的成像提供了互补信息。
