Polimeni P I, Cunningham P, Otten M D, McCrea D
Comput Biomed Res. 1987 Apr;20(2):113-24. doi: 10.1016/0010-4809(87)90039-5.
A method is described for quantifying the amount of atherosclerotic plaque in collapsible blood vessels by a computer-assisted image analysis of cross-sectional contours traced under microscopic visualization. The digitized contours are processed using a computer program that transforms the irregular image of the collapsed vessel into an ideal geometry and then calculates in vivo linear and areal parameters, variables, and ratios. The analysis is based on conventional stereologic principles and utilizes relatively inexpensive and widely available equipment: microscope with drawing tube attachment, digitizing board, microcomputer, monitor, and printer or plotter. Some of the output data include the fraction of vessel lumen occluded by plaque, average thickness of plaque, the fraction of wall surface area covered by plaque, and the ratio of the vessel bore to vessel wall volumes. The error and precision of measuring lumen occlusion and plaque surface area are assessed.
描述了一种通过对在显微镜下可视化追踪的横截面轮廓进行计算机辅助图像分析来量化可塌陷血管中动脉粥样硬化斑块数量的方法。使用计算机程序对数字化轮廓进行处理，该程序将塌陷血管的不规则图像转换为理想几何形状，然后计算体内线性和面积参数、变量及比率。该分析基于传统的体视学原理，并利用相对廉价且广泛可用的设备：带有绘图管附件的显微镜、数字化板、微型计算机、显示器以及打印机或绘图仪。一些输出数据包括被斑块阻塞的血管腔比例、斑块的平均厚度、被斑块覆盖的壁表面积比例以及血管内径与血管壁体积的比率。评估了测量管腔阻塞和斑块表面积的误差及精度。
