Manzardo S, Pinzetta A, Coppi G
Pharmacological and Toxicological Department, Poli Industria Chimica, Rozzano, Milan, Italy.
J Chemother. 1993 Oct;5(5):307-12. doi: 10.1080/1120009x.1993.11739250.
A new ciclopirox olamine vaginal preparation was tested for toxicity after topical vaginal administration for 28 days to rats and rabbits. At the end of the experiments animals were sacrificed for autopsy, the main organs were weighed, hematological, coagulative and biochemical parameters were checked and histological examinations were performed on uterus and vagina. The results demonstrated the good topical and systemic tolerance of this new vaginal formulation in rats and rabbits.
一种新的环吡酮胺阴道制剂在对大鼠和兔子进行28天的阴道局部给药后进行了毒性测试。实验结束时，处死动物进行尸检，称量主要器官重量，检查血液学、凝血和生化参数，并对子宫和阴道进行组织学检查。结果表明，这种新的阴道制剂在大鼠和兔子中具有良好的局部和全身耐受性。
