Nakamura T, Kyotani S, Kawasaki N, Tanada S, Nishioka Y
Faculty of Pharmaceutical Sciences, Kinki University, Osaka, Japan.
Nihon Eiseigaku Zasshi. 1993 Dec;48(5):973-9. doi: 10.1265/jjh.48.973.
Paraquat removal by chitosan with different substituents was investigated in vitro for evaluation of chitosan as a paraquat adsorbent in emergency treatment for acute paraquat poisoning. Chitosan CM and SU, in which the hydroxyl group at the C6 position is replaced by a carboxymethyl and sulfonic group, respectively, removed paraquat abundantly in purified water. However an inhibitory effect of sodium chloride on paraquat removal by CM and SU was recognized. On the other hand, paraquat removal by cross-linked chitosan (BCW) was accelerated in saline solutions. It was recognized that more paraquat was removed by BCW chitosan when the sodium chloride concentration was less than 1.8%. It was confirmed that some chitosan beads (CM and SU) could function as effective paraquat adsorbents through in vitro experiments.
研究了不同取代基壳聚糖对百草枯的体外去除效果，以评估壳聚糖作为百草枯吸附剂在急性百草枯中毒急救治疗中的作用。壳聚糖CM和SU中C6位的羟基分别被羧甲基和磺酸基取代，它们在纯水中能大量去除百草枯。然而，氯化钠对CM和SU去除百草枯有抑制作用。另一方面，交联壳聚糖（BCW）在盐溶液中对百草枯的去除作用加快。当氯化钠浓度低于1.8%时，BCW壳聚糖能去除更多的百草枯。通过体外实验证实，一些壳聚糖珠（CM和SU）可作为有效的百草枯吸附剂。
