Coiro V, Alboni A, Gramellini D, Cigarini C, Bianconi L, Pignatti D, Volpi R, Chiodera P
University Clinic of Internal Medicine, School of Medicine, University of Parma, Italy.
Acta Endocrinol (Copenh). 1992 Mar;126(3):213-6. doi: 10.1530/acta.0.1260213.
The possible inhibition exerted by ethanol on the oxytocin response to breast stimulation was tested in normal women. The possible role of endogenous opioids in the control of the oxytocin response to breast stimulation and/or ethanol action was also examined. Sixteen normal women were tested four times on the 22nd day of four consecutive regular menstrual cycles. All women underwent mechanical breast stimulation (for 10 min) with the concomitant administration of normal saline, naloxone (2 or 4 mg in an iv bolus plus 5 or 10 mg over 16 min), ethanol (50 ml in 110 ml of whisky po) or the combination of ethanol and naloxone. Plasma oxytocin levels rose about twofold after breast stimulation, with a mean peak response at 10 min. The oxytocin response to breast stimulation was not changed by the treatment with the lower (2 plus 5 mg) or the higher (4 plus 10 mg) dose of naloxone, whereas it was completely abolished by ethanol. However, when ethanol was given together with naloxone, the oxytocin rise induced by breast stimulation was only partially inhibited by ethanol (the mean oxytocin peak was 50% higher than baseline). At both doses naloxone produced similar effects. These data demonstrate that ethanol inhibits the oxytocin response to breast stimulation. Naloxone sensitive endogenous opioids do not appear to be involved in the control of the oxytocin rise induced by breast stimulation. In contrast, since naloxone partially reversed the inhibiting effects of ethanol, a partial involvement of opioid peptides in ethanol action is supposed.
在正常女性中测试了乙醇对催产素对乳房刺激反应的可能抑制作用。还研究了内源性阿片类物质在控制催产素对乳房刺激反应和/或乙醇作用中的可能作用。16名正常女性在连续四个正常月经周期的第22天接受了四次测试。所有女性均接受机械乳房刺激（持续10分钟），同时静脉注射生理盐水、纳洛酮（静脉推注2或4毫克，随后16分钟内再注射5或10毫克）、乙醇（口服50毫升110毫升威士忌）或乙醇与纳洛酮的组合。乳房刺激后血浆催产素水平升高约两倍，平均峰值反应出现在10分钟。较低剂量（2加5毫克）或较高剂量（4加10毫克）的纳洛酮治疗并未改变催产素对乳房刺激的反应，而乙醇则完全消除了该反应。然而，当乙醇与纳洛酮同时给予时，乳房刺激诱导的催产素升高仅被乙醇部分抑制（平均催产素峰值比基线高50%）。两种剂量的纳洛酮产生的效果相似。这些数据表明乙醇抑制催产素对乳房刺激的反应。纳洛酮敏感的内源性阿片类物质似乎不参与控制乳房刺激诱导的催产素升高。相反，由于纳洛酮部分逆转了乙醇的抑制作用，推测阿片肽在乙醇作用中部分参与。
