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[与小鼠成红细胞增多症抗原相似的人类红细胞核抗原标记物]

[Antigenic marker of human erythrokaryocytes similar to mouse erythroblastosis antigen].

作者信息

Ievleva E S, Ter-Grigorov V S, Graf I A, Pivnik A V, Idel'son L I

出版信息

Biull Eksp Biol Med. 1978 Sep;86(9):330-2.

PMID:81077
Abstract

Identical antigenic determinants are discovered on the surface of human erythrokaryocytes with antibodies against specific antigen of murine erythroblasts (Ag-Ed), previously revealed in study of Rauscher leukemia, in the immunofluorescent and cytotoxic tests. The antigen is present on the membranes of the majority of human embryonic liver and adult bone marrow nuclear erythroid cells, but is not found in fetal thymocytes, newborn kidney cells, adult human hepatic cells and in peripheral blood erythrocytes. Ag-Eb appears to possess an inter-species determinant, shared by mammalian nuclear erythroid cells, and may be used as their specific marker.

摘要

在免疫荧光和细胞毒性试验中,利用针对鼠成红细胞特异性抗原(Ag-Ed)的抗体,在人类红系核细胞表面发现了相同的抗原决定簇。该抗原先前在劳舍尔白血病研究中已被揭示。这种抗原存在于大多数人类胚胎肝脏和成人骨髓的核红系细胞的膜上,但在胎儿胸腺细胞、新生儿肾细胞、成人肝细胞以及外周血红细胞中未发现。Ag-Eb似乎具有一种跨物种的决定簇,为哺乳动物核红系细胞所共有,可用作它们的特异性标志物。

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