Radecki P
Muscle Nerve. 1994 Mar;17(3):325-30. doi: 10.1002/mus.880170311.
Epidemiological studies of the carpal tunnel syndrome have generally overlooked the possibility of a familial occurrence. A prospective study was undertaken to determine the prevalence and significance of a positive family history of carpal tunnel syndrome. Seventy-five of 253 women and 40 of 168 men with a confirmed carpal tunnel syndrome had at least one relative with symptoms of, or surgery for, carpal tunnel syndrome. A positive family history was predictive of a median abnormality or prior surgery at the carpal tunnel (chi-square = 20.484, P < 0.001). The 84 patients with a prior carpal tunnel surgery, likely the most well informed historically, had a positive family history of 39.3% versus 13.3% in the 279 patients without median latency slowing. The familial occurrence appears crucial in the epidemiological study of carpal tunnel syndrome, and may be important in the selection of normal subjects for electrodiagnostic standards.
腕管综合征的流行病学研究通常忽略了家族性发病的可能性。开展了一项前瞻性研究，以确定腕管综合征家族史阳性的患病率及意义。在确诊为腕管综合征的253名女性和168名男性中，分别有75名和40名至少有一名亲属有腕管综合征症状或接受过腕管综合征手术。家族史阳性可预测腕管处的中位异常或既往手术情况（卡方检验=20.484，P<0.001）。84例既往接受过腕管手术的患者（可能是历史上了解情况最多的患者），其家族史阳性率为39.3%，而在279例正中潜伏期未减慢的患者中，家族史阳性率为13.3%。家族性发病在腕管综合征的流行病学研究中似乎至关重要，并且在为电诊断标准选择正常受试者时可能也很重要。
