寡核苷酸探针设计——一种新方法。
Oligonucleotide probe design--a new approach.
作者信息
Mitsuhashi M, Cooper A, Ogura M, Shinagawa T, Yano K, Hosokawa T
机构信息
Advanced Gene Computing Technologies (AGCT), Inc, Irvine, California 92715.
出版信息
Nature. 1994 Feb 24;367(6465):759-61. doi: 10.1038/367759a0.
DOI:10.1038/367759a0
PMID:8107873
Abstract
The use of oligonucleotides for gene amplification, as diagnostic probes or antisense-based drugs can be optimized by minimizing the possibility of nonspecific hybridization.
摘要
将寡核苷酸用作基因扩增、诊断探针或基于反义的药物时，可通过将非特异性杂交的可能性降至最低来实现优化。
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