van Erpecum K J, van de Meeberg P C, van Berge Henegouwen G P
Department of Gastroenterology, University Hospital, Utrecht, Netherlands.
Neth J Med. 1993 Dec;43(5-6):233-8.
Ursodeoxycholic acid is increasingly used in the treatment of a variety of cholestatic diseases such as primary biliary cirrhosis. The present article summarizes current understanding of the mechanism of action of ursodeoxycholic acid in these diseases. Apart from a direct hepatoprotective effect, ursodeoxycholic acid also influences the enterohepatic circulation with decreased ileal reabsorption and increased faecal excretion of potentially hepatotoxic endogenous bile salts. In addition, a cholehepatic shunt mechanism and immune modulating effects may also be important.
熊去氧胆酸越来越多地用于治疗各种胆汁淤积性疾病，如原发性胆汁性肝硬化。本文总结了目前对熊去氧胆酸在这些疾病中的作用机制的认识。除了直接的肝保护作用外，熊去氧胆酸还通过减少回肠重吸收和增加潜在肝毒性内源性胆汁盐的粪便排泄来影响肠肝循环。此外，胆肝分流机制和免疫调节作用也可能很重要。
