Luketic V A, Sanyal A J
Section of Hepatology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.
Gastroenterologist. 1994 Mar;2(1):74-9.
Cholestasis results from either failure of bile formation or obstruction to bile flow. Liver diseases characterized by chronic cholestasis frequently cause progressive hepatocellular injury, cirrhosis, and death. Recent studies have shown that bile salts have an important role in the genesis and maintenance of liver injury in chronic cholestatic liver diseases. Ursodeoxycholic acid, a unique bile acid, protects the liver from injury by harmful bile acids and has been shown to improve symptoms and to delay the onset of liver failure and complications of cirrhosis. The rationale for its use and the results from clinical trials in chronic cholestasis are reviewed. Recommendations for the use of ursodeoxycholic acid in chronic cholestatic liver diseases are provided.
胆汁淤积是由胆汁形成障碍或胆汁流动受阻引起的。以慢性胆汁淤积为特征的肝脏疾病常导致进行性肝细胞损伤、肝硬化和死亡。最近的研究表明，胆盐在慢性胆汁淤积性肝病的肝损伤发生和维持中起重要作用。熊去氧胆酸是一种独特的胆汁酸，可保护肝脏免受有害胆汁酸的损伤，并已被证明可改善症状，延缓肝衰竭的发生和肝硬化的并发症。本文综述了其使用的理论依据以及慢性胆汁淤积临床试验的结果。并提供了熊去氧胆酸在慢性胆汁淤积性肝病中使用的建议。
