Kjellberg B, Randrup A
Psychopharmacologia. 1975 Sep 17;43(3):267-9. doi: 10.1007/BF00429262.
Desmethylimipramine (DMI) exerts diverse quantitative effects on the gross behaviour of monkeys. Excitatory as well as sedative effects were observed, which varied according to the general animal temperament. Results resembling those obtained with DMI were observed using chlorimipramine and iprindole, although the effects of iprindole were less marked. Chlorimipramine also produced immobilization and postural change. The results are discussed in relation to behavioral effects of thymoleptics in humans, and the use of monkeys in preclinical testing of thymoleptic drugs is suggested.
去甲丙咪嗪（DMI）对猴子的总体行为产生多种定量影响。观察到兴奋和镇静作用，这些作用因动物的一般性情而异。使用氯米帕明和茚满二酮时观察到了与DMI相似的结果，尽管茚满二酮的作用不太明显。氯米帕明还会导致动物固定不动和姿势改变。结合抗抑郁药对人类的行为影响对这些结果进行了讨论，并建议在抗抑郁药的临床前测试中使用猴子。
