Pavlov A V, Dobordzhginidze T R, Miro T L, Aleksandrov Iu K
Probl Endokrinol (Mosk). 1993 Sep-Oct;39(5):49-51.
Structure and function of the regenerating thyroid fragment were studied in 18 adult white rats 30 days after partial resection of centromedial or peripheral fragments of the lobes similar in size using quantitative methods (organometry, histometry, measurements of blood serum hormones). The volume of glandular tissue removed in two series of experiments was 40 and 75% of the total thyroid mass of experimental animals. Centromedial portions of the thyroid of intact rats were characterized by greater follicular epithelium volume (by 10%) and C-cell content per section area (six-fold), as well as by a lesser mean diameter of the follicles (by 26%) and colloid volumic fraction (by 40%) in comparison with the peripheral segments. No reliable differences in the quantitative structural parameters (mass, tissue component volumic fractions, mean follicular diameter and follicular epithelium height) and hormonal activity of the regenerated tissue in the two variants of surgery were observed. The results indicate that thyroid parenchyma of various portions of the organs is similarly capable of full-value regeneration.
在18只成年白色大鼠中,采用定量方法(器官测量法、组织测量法、血清激素测定)研究了在部分切除大小相似的叶的中央内侧或周边片段30天后再生甲状腺片段的结构和功能。在两组实验中切除的腺组织体积分别为实验动物甲状腺总质量的40%和75%。与周边部分相比,完整大鼠甲状腺的中央内侧部分的特点是滤泡上皮体积更大(大10%),每单位截面积的C细胞含量更多(多6倍),以及滤泡平均直径更小(小26%)和胶体体积分数更小(小40%)。在两种手术变体中,再生组织的定量结构参数(质量、组织成分体积分数、滤泡平均直径和滤泡上皮高度)和激素活性均未观察到可靠差异。结果表明,器官不同部分的甲状腺实质同样能够进行充分的再生。