Rodrigues C J, Levy J A, Carvalho M, Rodrigues Júnior A J, De Barros Filho T E, Cossermelli W
Laboratory of Rheumatology, Faculdade de Medicina, Universidade de São Paulo, Brasil.
Rev Paul Med. 1993 May-Jun;111(3):417-21.
A series of 110 muscle and 40 skin biopsy specimens were examined using direct immunofluorescence aiming to identify features that may differentiate the myopathy of connective tissue disease from other muscle diseases. The skeletal muscle fluorescence was positive in 75% of the patients with muscle diseases. The sarcolemmal staining was higher in mitochondrial encephalomyopathy. Fiber and vascular staining occurred in all muscle diseases, except in cases of myasthenia. Our results showed that 42% of patients with polymyositis and 43% of patients with peripheral motor neuron diseases have vascular deposits of immune complexes suggesting that these two diseases could result from an immune-complex-induced vasculopathy. The IF test in skin specimens was positive in 60% of the patients with muscular diseases. The absence of immunoglobulin deposit at the dermoepidermal junction and at epidermal nuclei in cases of peripheral motor neuron disease suggest that this skin test may be useful in the differentiation of muscle diseases.
对110份肌肉活检标本和40份皮肤活检标本进行了直接免疫荧光检查，旨在识别可能将结缔组织病性肌病与其他肌肉疾病区分开来的特征。75%的肌肉疾病患者骨骼肌荧光呈阳性。线粒体脑肌病的肌膜染色更高。除重症肌无力外，所有肌肉疾病均出现纤维和血管染色。我们的结果表明，42%的多发性肌炎患者和43%的周围运动神经元疾病患者有免疫复合物的血管沉积，提示这两种疾病可能由免疫复合物诱导的血管病变引起。60%的肌肉疾病患者皮肤标本的免疫荧光试验呈阳性。周围运动神经元疾病患者在真皮表皮交界处和表皮细胞核处无免疫球蛋白沉积，提示该皮肤试验可能有助于肌肉疾病的鉴别。
