Hanson P A, Urizar R E
Ann Neurol. 1977 May;1(5):431-7. doi: 10.1002/ana.410010506.
Thirteen sequential percutaneous skeletal muscle biopsy specimens from 4 patients with Reye's syndrome were studied ultrastructurally and by direct immunofluorescence. Prominent generalized intermyofibrillar edema, mitochondrial disruption, and swelling of vascular endothelium were demonstrated in 2 patients. In all 4 patients there were granular deposits of immunoglobulins G and M in intramuscular vessels, presumably representing antigen-antibody complexes. We postulate that these changes may be pathogenetically important in this syndrome and suggest that muscle biopsy tissue be utilized for further investigation of Reye's syndrome.
对4例瑞氏综合征患者的13份连续经皮骨骼肌活检标本进行了超微结构和直接免疫荧光研究。在2例患者中发现了明显的广泛性肌原纤维间水肿、线粒体破坏和血管内皮肿胀。在所有4例患者的肌内血管中均有免疫球蛋白G和M的颗粒状沉积，推测代表抗原抗体复合物。我们推测这些变化在该综合征的发病机制中可能具有重要意义，并建议利用肌肉活检组织对瑞氏综合征进行进一步研究。
