Laurent J P, Molinari G F, Moseley J I
Surg Neurol. 1975 Nov;4(5):449-55.
A method recently developed in our laboratory has been evaluated for clinical and pathological reliability and validity. Intracarotid injection of a silicone polymer molded into an elastic cylinder regularly caused segmental occlusion of the middle cerebral artery in sedated but conscious rhesus monleys. Clinical changes were quantitatively monitored continuously from onset through acute and chronic phases and precise correlations made with postmortem vascular and parenchymal pathology. Minor anatomical variations in the size and branching patterns of the middle cerebral artery in this primate species paralleled those in man. Uniformity in patterns of the acute natural history and specificity in clinical pathological correlations substantiate the utility of this stroke model for tests of therapeutic efficacy.
我们实验室最近开发的一种方法已针对临床及病理的可靠性和有效性进行了评估。将硅酮聚合物模制成弹性圆柱体后经颈内动脉注射，在麻醉但清醒的恒河猴中通常会导致大脑中动脉节段性闭塞。从发病开始，通过急性期和慢性期持续对临床变化进行定量监测，并与死后血管及实质病理进行精确关联。这种灵长类动物大脑中动脉在大小和分支模式上的微小解剖变异与人类相似。急性自然病史模式的一致性以及临床病理关联的特异性证实了该中风模型在治疗效果测试中的实用性。
