灵长类动物中由细菌植入和脓毒性栓塞引起的脑脓肿。

Wood J H, Lightfoote W E, Ommaya A K

J Neurol Neurosurg Psychiatry. 1979 Jan;42(1):63-9. doi: 10.1136/jnnp.42.1.63.

The degree of brain abscess encapsulation is positively related to surgical mortality and methods to enhance capsule wall formation, therefore, have therapeutic relevance. Two primate models are described which may be useful in the investigation of encapsulation of traumatic and metastatic brain abscesses. Direct intracerebral inoculation induces abscesses displaying more prominent inflammatory responses and encapsulation than does septic embolisation, despite similar abscess age and size. Cerebral ischaemia surrounding metastatic suppurative foci may retard capsule wall formation.

脑脓肿包膜形成程度与手术死亡率呈正相关，因此，增强包膜形成的方法具有治疗意义。本文描述了两种灵长类动物模型，它们可能有助于研究创伤性和转移性脑脓肿的包膜形成。尽管脓肿的年龄和大小相似，但与脓毒性栓塞相比，直接脑内接种诱导的脓肿表现出更明显的炎症反应和包膜形成。转移性化脓灶周围的脑缺血可能会延缓包膜形成。