Linseisen J, Wolfram G
Institute of Nutrition Science, Technical University of Munich, FRG.
Ann Nutr Metab. 1993;37(6):328-34. doi: 10.1159/000177784.
For 11 days, an odd-numbered medium-chain triglyceride (trinonanoin, C9TG)/long-chain triglyceride (LCT) emulsion was given parenterally to rabbits, providing 46.5% of total energy. In comparison with LCT or MCT/LCT fat emulsions, no negative effects on organ weights and liver lipid concentrations were noted. In some rabbits of the C9TG/LCT group macroscopically but not histologically visible liver changes were observed. The extent of nonanoic acid deposition in liver triglycerides, liver phospholipids, adipose tissue and skeletal muscle after C9TG/LCT administration was similar to C8/C10 deposition in the MCT/LCT group; the enrichment of adipose tissue with 16 mol% was higher than expected.
连续11天，将奇数链中链甘油三酯（三壬酸甘油酯，C9TG）/长链甘油三酯（LCT）乳剂经肠外途径给予家兔，其提供的能量占总能量的46.5%。与LCT或MCT/LCT脂肪乳剂相比，未观察到对器官重量和肝脏脂质浓度的负面影响。在C9TG/LCT组的一些家兔中，观察到肝脏有肉眼可见但组织学上不可见的变化。给予C9TG/LCT后，肝脏甘油三酯、肝脏磷脂、脂肪组织和骨骼肌中壬酸的沉积程度与MCT/LCT组中C8/C10的沉积相似；脂肪组织中16摩尔%的富集高于预期。
