Fukuda H, Ichihashi M, Mishima Y
Institute of Development, Aging and Cancer, Tohoku University.
Gan To Kagaku Ryoho. 1994 Feb;21(3):374-8.
Boron neutron capture therapy (BNCT) is a selective radiotherapy using boron-10 which absorbs thermal neutrons and releases high LET alpha particles by 10B(n, alpha)7Li reaction. In this paper, the present status of BNCT for malignant melanoma was introduced. As a melanoma-targetting 10B-compound, 10B-paraboronophylalanine (BPA) was used. It was administered by multiple subcutaneous injection or intravenous drip infusion. We adopted the maximum tolerance dose to the skin as a therapeutic dose regardless of the tumor 10B concentration, because we cannot directly measure it. For this purpose, an approximation of skin concentration was made using blood data just after the administration. We treated 14 melanoma patients in this way and obtained good local control of the tumor with tolerable skin reaction. More experience with logical analysis and basic research is necessary for further development of this therapy.
硼中子俘获疗法（BNCT）是一种利用硼 - 10的选择性放射疗法，硼 - 10吸收热中子并通过10B(n,α)7Li反应释放高传能线密度的α粒子。本文介绍了BNCT治疗恶性黑色素瘤的现状。作为一种靶向黑色素瘤的硼 - 10化合物，使用了10B - 对硼苯丙氨酸（BPA）。通过多次皮下注射或静脉滴注给药。由于无法直接测量肿瘤硼 - 10浓度，我们将皮肤的最大耐受剂量作为治疗剂量，而不考虑肿瘤硼 - 10浓度。为此，在给药后立即使用血液数据对皮肤浓度进行近似估算。我们用这种方法治疗了14例黑色素瘤患者，在可耐受的皮肤反应下实现了对肿瘤良好的局部控制。为了该疗法的进一步发展，需要更多逻辑分析和基础研究方面的经验。
