胆碱酯酶抑制剂对琥珀酰胆碱神经肌肉阻滞作用的影响。

Effects of cholinesterase inhibitors on the neuromuscular blocking action of suxamethonium.

作者信息

Valdrighi J B, Fleming N W, Smith B K, Baker G L, White D A

机构信息

Department of Anesthesiology, University of California Davis 95616.

出版信息

Br J Anaesth. 1994 Feb;72(2):237-9. doi: 10.1093/bja/72.2.237.

DOI:10.1093/bja/72.2.237

PMID:8110583

Abstract

Prolonged neuromuscular block occurs when suxamethonium is given after neostigmine or pyridostigmine; however, studies of edrophonium and suxamethonium have yielded conflicting results. We have studied, therefore, interactions between suxamethonium and all three anticholinesterases in rats anaesthetized with pentobarbitone. After recovery from an initial bolus of suxamethonium, saline, edrophonium, pyridostigmine or neostigmine was administered and a second dose of suxamethonium was then given. All three anticholinesterases prolonged the duration of neuromuscular block (90% suppression to 50% twitch recovery) to 127 (SEM 9)%, 127(10)% and 138 (11)% of baseline for edrophonium, pyridostigmine and neostigmine, respectively. Recovery index (25% to 75% twitch recovery) was increased also to 125 (9)%; 149 (10%) and 185 (15)% of baseline, respectively for the three drugs.

摘要

在新斯的明或吡啶斯的明之后给予琥珀胆碱时会发生长时间的神经肌肉阻滞；然而，依酚氯铵与琥珀胆碱的研究结果相互矛盾。因此，我们研究了在戊巴比妥麻醉的大鼠中琥珀胆碱与所有三种抗胆碱酯酶之间的相互作用。在从初始推注的琥珀胆碱恢复后，给予生理盐水、依酚氯铵、吡啶斯的明或新斯的明，然后给予第二剂琥珀胆碱。所有三种抗胆碱酯酶均将神经肌肉阻滞的持续时间（从90%抑制到50%抽搐恢复）延长至依酚氯铵、吡啶斯的明和新斯的明分别为基线的127（标准误9）%、127（10）%和138（11）%。恢复指数（从25%到75%抽搐恢复）也分别增加至三种药物基线的125（9）%、149（10%）和185（15）%。