Faber J
Acta Univ Carol Med Monogr. 1975(64):1-78.
Relationship between amplitude and interval of healthy and epileptic children's alpha activity was investigated. A directly proportional, though non-linear (mostly exponential) correlation was found, i. e. the higher the waves, the wider their are, and vice versa, the lower, the narrower. This is a well-known feature of clinical electroencephalography, representing a good organization of EEG elements and, in terms of physiology, suggesting good "co-operation" of the recruitment process excitation and inhibition. Low interval values are matched by equally low amplitude values while inhibition is adequate. At higher interval values, amplitude is seen rising rapidly, inhibition is inadequate resulting in "paroxysmal" alpha activity which is occasionally found assuming the nature of spike and slow wave activity. The appearance of such principal changes in the recruitment process is abrupt, but a certain part of the changes often fails to manifest itself in the EEG curve. Epileptic children's alpha activity has a relatively higher amplitude, slower rhythm and a more regular regulation of amplitudes and intervals as well as that of their ratio. This is in line with the tendency toward hypersynchrony of EEG elements in epileptics. Epileptic spike and wave activity has an opposite sense of regulation as to the relationship of spike amplitudes and intervals, the principle being: the higher the spikes, the shorter the intervals between them. Apart from frequency, amplitude and angular velocity, that is another substantial difference between alpha activity physiological synchronization in vigilance and pathological spike hypersynchronization in petit mal seizure. Changes in vigilance seem to be in agreement with this phenomenon. The nature of recruitment process regulation (given in type of function) appears to be very stable, often remaining unchanged even under pathological conditions. Thus e. g. aplha wave recruitment during vigilance and spike recruitment during seizure are linear in either case. But while in alpha activity the amplitude-interval ratio is directly proportional, in spikes the proportionality is inverse. Alpha activity appears to be accompanied by inhibitory processes, spikes by excitatory processes. The number of active neurones and their synchronization in the course of spike-wave episodes is higher than during alpha activity. For that reason, in the course of epileptic recruitment process, expedient temporal-spatial integration of neuronal activity decreases to be superceded by simplified hypersynchronous reverberation with lower analytical-synthetic ability and lower reflectivity.
研究了健康儿童和癫痫儿童阿尔法活动的波幅与间期之间的关系。发现两者呈正比关系，但并非线性关系（大多呈指数关系），即波幅越高，间期越宽；反之，波幅越低，间期越窄。这是临床脑电图的一个众所周知的特征，代表了脑电图元素的良好组织，从生理学角度来看，表明募集过程中兴奋与抑制的良好“协作”。当抑制充分时，低间期值与同样低的波幅值相对应。在较高的间期值时，波幅迅速上升，抑制不足，导致偶尔出现具有棘波和慢波活动性质的“阵发性”阿尔法活动。募集过程中这种主要变化的出现是突然的，但其中一部分变化往往未能在脑电图曲线上表现出来。癫痫儿童的阿尔法活动具有相对较高的波幅、较慢的节律，以及对波幅、间期及其比值的更规则调节。这与癫痫患者脑电图元素超同步化的趋势一致。癫痫棘波和慢波活动在棘波波幅与间期的关系上具有相反的调节意义，原则是：棘波越高，它们之间的间期越短。除了频率、波幅和角速度外，这也是清醒时阿尔法活动生理同步与失神发作时病理性棘波超同步之间的另一个重要区别。警觉性的变化似乎与这一现象相符。募集过程调节的性质（以函数类型表示）似乎非常稳定，即使在病理条件下也常常保持不变。例如，清醒时阿尔法波的募集和发作时棘波的募集在任何情况下都是线性的。但在阿尔法活动中，波幅 - 间期比值是正比关系，而在棘波中则是反比关系。阿尔法活动似乎伴随着抑制过程，棘波则伴随着兴奋过程。棘波 - 慢波发作过程中活跃神经元的数量及其同步性高于阿尔法活动期间。因此，在癫痫募集过程中，神经元活动的适时时空整合减少，被具有较低分析 - 合成能力和较低反射率的简化超同步回响所取代。
