Filipppov V N, Podosinovikova N P, Kosmachev A B, Dolgo-Saburov V B
Eksp Klin Farmakol. 1993 Nov-Dec;56(6):57-8.
The results of in vitro and in vivo experiments were used to compare the capacity of bispiridinium oximes to modulate the presynaptic secretion of acetylcholine and to demonstrate the protective activity against organophosphate intoxication during combined application with various M-cholinolytics. It is suggested that bispiridinium oximes combined with M-cholinolytics can play a corrective role in eliminating the adverse presynaptic effect of a cholinolytic, thus lowering the severity of intoxication.
体外和体内实验结果用于比较双吡啶肟调节乙酰胆碱突触前分泌的能力，并证明在与各种M胆碱解磷定联合应用时对有机磷中毒的保护活性。有人认为，双吡啶肟与M胆碱解磷定联合使用可在消除胆碱解磷定的不良突触前效应方面发挥纠正作用，从而降低中毒的严重程度。
