Kosmachev A B, Filippov V N, Kosmacheva I M, Khobotova Z I, Kuleshov V I
Farmakol Toksikol. 1991 Jul-Aug;54(4):67-9.
Under the conditions of the constancy of the postsynaptic effect of two M-cholinolytics atropine and amizil the relationship between the presynaptic and protective effects of the drugs in DDVF intoxication was studied. The indication of the level of the postsynaptic activity was the suppression by the cholinolytics of tremor reaction in rats induced by the action of arecoline. The presynaptic effect of the drugs was judged by the charge of the "bound" acetylcholine content in the brains of the animals. It was found that when administered in the equieffective by the choline-blocking activity doses, atropine to a greater extent reduced the content of the "bound" acetylcholine which was increased due to the action of DDVF and at the same time it possessed the less pronounced protective activity in intoxication with DDVF than amizil. It is supposed that the removal of the presynaptic suppression of acetylcholine release due to the anticholinesterase substance action deteriorates the prognosis of the course of DDVF intoxication.
在两种M胆碱阻断剂阿托品和阿米齐尔的突触后效应恒定的条件下，研究了药物在敌敌畏中毒时的突触前效应与保护作用之间的关系。突触后活性水平的指标是胆碱阻断剂对槟榔碱作用诱导的大鼠震颤反应的抑制。药物的突触前效应通过动物脑中“结合”乙酰胆碱含量的变化来判断。结果发现，当以胆碱阻断活性的等效剂量给药时，阿托品在更大程度上降低了因敌敌畏作用而增加的“结合”乙酰胆碱含量，同时在敌敌畏中毒时其保护活性比阿米齐尔弱。据推测，抗胆碱酯酶物质作用导致的乙酰胆碱释放突触前抑制的消除会使敌敌畏中毒病程的预后恶化。
