Schein O D, West S, Muñoz B, Vitale S, Maguire M, Taylor H R, Bressler N M
Dana Center for Preventive Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Invest Ophthalmol Vis Sci. 1994 Feb;35(2):363-6.
To examine the distribution of cortical opacification of the lens by lens quadrant in a longitudinal study.
In 1990, a follow-up assessment of a cohort of Chesapeake Bay watermen, initially studied in 1985, was performed. Four hundred thirty-seven subjects (834 eyes) had gradable cortical photographs for at least one eye in both 1985 and 1990. Cortical photographs were graded by both estimating total area and determining the quadrant with the greatest degree of cortical opacification.
The prevalence and severity of cortical opacification increased with age with a high degree of concordance (84%) between eyes. For the 47 eyes with cortical opacification > or = 1/8 at baseline, the principal locations of opacification were: inferonasal 63.8%, inferotemporal 17.0%, superonasal 6.4%, and superotemporal 12.8% (P < 0.001, compared with equal distribution by quadrant). Five-year development of new cortical opacification and five-year progression of existing cortical opacification showed even greater preferential occurrence in the inferonasal quadrant of the lens.
In this population, the inferonasal quadrant of the lens is the principal site of cortical opacification in both cross-sectional and longitudinal assessment. This finding is consistent with the hypothesis that sunlight exposure is a significant risk factor for cortical opacification.
在一项纵向研究中，按晶状体象限检查晶状体皮质混浊的分布情况。
1990年，对一组切萨皮克湾渔民进行了随访评估，这些渔民最初于1985年接受研究。437名受试者（834只眼）在1985年和1990年至少有一只眼有可分级的皮质照片。通过估计总面积和确定皮质混浊程度最高的象限对皮质照片进行分级。
皮质混浊的患病率和严重程度随年龄增加，双眼之间的一致性较高（84%）。对于基线时皮质混浊≥1/8的47只眼，混浊的主要部位为：鼻下63.8%，颞下17.0%，鼻上6.4%，颞上12.8%（与象限均匀分布相比，P<0.001）。新皮质混浊的五年发展和现有皮质混浊的五年进展在晶状体鼻下象限的发生率更高。
在这一人群中，在横断面和纵向评估中，晶状体鼻下象限是皮质混浊的主要部位。这一发现与阳光照射是皮质混浊的重要危险因素这一假设一致。
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